To explore whether different p53 expression levels affect the level of angiogenesis in vitro, HUVECs were cocultured with the p53 inducer or inhibitor for 24 h
Glutathione's role in mitochondrial protection means that cellular energy production becomes more efficient as oxidative burden declines
Its activity profile is best understood as systems-level: published in vitro and in vivo work has documented effects on fibroblast proliferation, collagen and growth-factor receptor expression, endothelial migration, nitric oxide system signalling, and dopamine and serotonin pathway markers
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Khavinson VK, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B